Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?10/2/2023 ![]() Here we report for the first time that t-PA potentiates signaling mediated by glutamatergic receptors by modifying the properties of the N-methyl-D-aspartate (NMDA) receptor. ![]() In contrast, the results of animal studies have indicated that t-PA could increase neuronal damage after focal cerebral ischemia. Tissue-plasminogen activator (t-PA) is now available for the treatment of thrombo-embolic stroke but adverse effects have been reported in some patients, particularly hemorrhaging.
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